efficient ball mill procedure in the green asymmetric aldol reaction

Efficient ball-mill procedure in the ‘green’ asymmetric ...

2011-9-9  The organocatalytic activity of (S)-proline-based dipeptides 1a–c has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solvent-free conditions in a ball mill.In particular, the methyl ester of (S)-proline-(S)-tryptophan, (S,S)-1c, proved to be an efficient organocatalyst, and the aldol reaction proceeded with good chemical ...

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ChemInform Abstract: Efficient Ball-Mill Procedure in the ...

ChemInform Abstract: Efficient Ball-Mill Procedure in the ′Green′ Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water.

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10.1016/j.tet.2011.06.042 10.1016/j.tet.2011 ... - DeepDyve

The desired aldol products were obtained in high yields (up to 94%) and good enantioselectivities (up to 97% ee). 17a In addition, Li and co-workers examined dipeptide ( 1c -OH) in the asymmetric aldol reaction of different ketones and aldehydes in solid phase media (Al 2 O 3 ), using 1,4-diazabicyclo[2.2.2]octane as additive, observing ...

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A Highly Efficient Asymmetric Organocatalytic Aldol ...

Request PDF A Highly Efficient Asymmetric Organocatalytic Aldol Reaction in a Ball Mill Anti-aldol products with up to >99 % enantiomeric excess (ee) have been obtained by proline catalysis in ...

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Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline ...

2011-1-20  The organocatalytic activity of the methyl ester of (S)-proline-(S)-phenylalanine, (S,S)-2, in the asymmetric aldol reaction between cyclohexanone and acetone with various aromatic aldehydes under solvent-free conditions in a ball mill has been evaluated. α,α-Dipeptide (S,S)-2 catalyzed the stereoselective formation of the expected aldol products, with higher diastereo- and ...

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Highly Efficient Small Organic Molecules for ...

2009-5-7  Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011, 67 (36) , 6953-6959. DOI: 10.1016/j.tet.2011.06.042.

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The Ion Tag Strategy as a Route to Highly Efficient ...

José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).

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Ball Milling - University of Massachusetts Boston

2020-4-9  Ball Milling An efficient and ecologically friendly synthetic approach ‐‐‐ Jackie Ding . Ball milling – solvent free approach Application in organic synthesis Conclusion Content 2 . The 12 Principles of Green Chemistry ... Planetary Ball Mill PM 400 Feed material: soft, hard,

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Dr Eusebio Juaristi Areas de Investigacion

2021-4-20  (3) J.G. Hernández y E. Juaristi, “Efficient Ball-Mill Procedure in the “Green” Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water”, Tetrahedron, 67, 6953-6959 (2011).

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José G. Hernández's research works Instituto Politécnico ...

ChemInform Abstract: Efficient Ball-Mill Procedure in the ′Green′ Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water. Article Sep 2011

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(PDF) Proline−β 3 -Amino-Ester Dipeptides as Efficient ...

Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by ( S)-proline-containing dipeptides in the presence of water By Eusebio Juaristi Novel prolinamideeureas as organocatalysts for the asymmetric aldol reaction

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A green look at the aldol reaction - Green Chemistry (RSC ...

Introduction The aldol reaction is one of the most powerful and best known C–C forming synthetic reactions, universally present in basic and advanced organic chemistry texts and amply reviewed in organic synthetic books and series. 1–4 The reaction has industrial relevance either in bulk production, or in the fine chemical and pharmaceutical industry. 5 The aldol reaction has a particular ...

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Natural low-molecular mass organic compounds with

2014-12-2  (2011) Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 67 ( 36 ): 6953 – 6959 OpenUrl CrossRef

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Natural low-molecular mass organic compounds with

2014-12-2  Hernández JG, Juaristi E. Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron. 2011; 67 (36):6953–6959.

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Ball Milling - University of Massachusetts Boston

2020-4-9  Ball Milling An efficient and ecologically friendly synthetic approach ‐‐‐ Jackie Ding . Ball milling – solvent free approach Application in organic synthesis Conclusion Content 2 . The 12 Principles of Green Chemistry ... Planetary Ball Mill PM 400 Feed material: soft, hard,

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Диссертация на тему «Разработка ...

132. Hernández J.G., Juaristi E. Efficient ball-mill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water// Tetrahedron Lett., 2011, Vol. 67, № 36, P. 6953-6959 133.

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European Journal of Organic Chemistry: EarlyView ...

2021-11-19  The asymmetric aldol reaction of an industrially viable synthesis of funapide, a promising analgesic agent, was studied with a range of squaramide catalysts. Compared to previously employed thiourea structures, these catalysts provided a non

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Dr Eusebio Juaristi Areas de Investigacion

2021-4-20  (3) J.G. Hernández y E. Juaristi, “Efficient Ball-Mill Procedure in the “Green” Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water”, Tetrahedron, 67, 6953-6959 (2011).

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许丹倩_百度百科

2006-7-26  Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill. Green Chem., 2012, 14, 893；SCI 915IU；IF：6.8283. Fischer indole synthesis catalyzed by novel SO3H-functionalized ionic liquids in water.

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(PDF) Proline−β 3 -Amino-Ester Dipeptides as Efficient ...

Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by ( S)-proline-containing dipeptides in the presence of water By Eusebio Juaristi Novel prolinamideeureas as organocatalysts for the asymmetric aldol reaction

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Natural low-molecular mass organic compounds with

2014-12-2  (2011) Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 67 ( 36 ): 6953 – 6959 OpenUrl CrossRef

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Highly Efficient Asymmetric Direct Stoichiometric Aldol ...

Angewandte Chemie DOI: 10.1002/ange.200703606 Asymmetric Synthesis Highly Efficient Asymmetric Direct Stoichiometric Aldol Reactions on/in Water** Junmin Huang, Xiaotong Zhang, and Daniel W. Armstrong* Many enzymes catalyze reactions in water under mild example, proline-catalyzed aldol reactions[10] can only afford conditions with high efficiency and excellent stereoselectivity.

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A highly efficient solvent-free asymmetric direct aldol ...

2008-7-4  Three different methods are assayed: simple conventional magnetic stirring, magnetic stirring after previous dissolution in THF and evaporation, and ball mill technique. These procedures allow one to reduce not only the amount of required ketone to 2 equiv but also the reaction time to give the aldol products with regio-, diastereo-, and ...

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Asymmetric Catalysis - Home ICM

[23] Hernández J.G., Juaristi E., Efficient ball-mill procedure inthe ‘green’ asymmetric aldol reaction organocatalyzed by(S)-proline-containing dipeptides in the presence of

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RUA: A Highly Efficient Solvent-Free Asymmetric Direct ...

2017-11-23  A Highly Efficient Solvent-Free Asymmetric Direct Aldol Reaction Organocatalyzed by Recoverable (s)-Binam-L-Prolinamides. ... and ball mill technique. These procedures allow one to reduce not only the amount of required ketone to 2 equiv but also the reaction time to give the aldol products with regio-, diastereo-, and enantioselectivities ...

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Dr Eusebio Juaristi Areas de Investigacion

2021-4-20  (3) J.G. Hernández y E. Juaristi, “Efficient Ball-Mill Procedure in the “Green” Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water”, Tetrahedron, 67, 6953-6959 (2011).

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Solvent-free enantioselective organocatalyzed aldol

2016-5-5  solvent media. The first solvent-free intermolecular aldol reaction involved the use of a ball mill [22]. This technique [23] is widely applied in grinding minerals and solids into fine particles and it was used in this transformation in order to enhance the efficient mixing of

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Диссертация на тему «Разработка ...

132. Hernández J.G., Juaristi E. Efficient ball-mill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water// Tetrahedron Lett., 2011, Vol. 67, № 36, P. 6953-6959 133.

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Organocatalysis in aqueous media Nature Reviews

2019-7-17  In terms of aqueous reactions, catalysts that activate a carbonyl substrate to form an enamine and iminium, typically as part of an overall asymmetric aldol reaction, have received the most ...

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